Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.7
USERS' SCORE
Good
Based on 5 Reviews
8.4
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Vitamin B12 (as Methylcobalamin)
1,500 mcg
62500%
Top Medical Research Studies
9
We explored how methylcobalamin, a form of vitamin B12, impacts liver disease, particularly in the context of cholestatic liver failure. The study utilized high-throughput screening to identify methylcobalamin as a specific inhibitor of gasdermin E (GSDME), a protein that plays a key role in pyroptotic cell death—a form of inflammatory cell death contributing to liver damage.
Our findings showed that when tested on mouse models with liver failure due to cholestasis, cisplatin, or concanavalin A, methylcobalamin effectively reduced liver damage. It significantly lowered liver transaminase levels, indicating less liver inflammation and cellular injury, and helped alleviate overall liver cell death.
Furthermore, methylcobalamin worked by preventing the cleavage of GSDME, which is essential for uncontrolled inflammatory cell death. By binding to a specific site on the GSDME protein, it blocked the interactions that trigger this damaging process. Overall, our study highlighted the potential of methylcobalamin as a promising therapeutic option for managing cholestatic liver failure and related conditions.
Our findings showed that when tested on mouse models with liver failure due to cholestasis, cisplatin, or concanavalin A, methylcobalamin effectively reduced liver damage. It significantly lowered liver transaminase levels, indicating less liver inflammation and cellular injury, and helped alleviate overall liver cell death.
Furthermore, methylcobalamin worked by preventing the cleavage of GSDME, which is essential for uncontrolled inflammatory cell death. By binding to a specific site on the GSDME protein, it blocked the interactions that trigger this damaging process. Overall, our study highlighted the potential of methylcobalamin as a promising therapeutic option for managing cholestatic liver failure and related conditions.
Read More
9
Methylcobalamin improves nerve myelination
We delved into the effects of methylcobalamin, a form of vitamin B12, on nerve myelination in rats suffering from moderate hepatic encephalopathy, a condition caused by ammonia toxicity due to liver dysfunction. In our study, we established a model of hepatic encephalopathy by administering thioacetamide to induce liver damage, subsequently leading to changes in nerve myelination in specific brain regions.
We focused on the hippocampus, an area crucial for memory and learning, where we noted significant reductions in myelin levels and myelin basic protein (MBP) quantities in the affected rats. However, after administering methylcobalamin for a week, we observed a remarkable recovery in the myelination status, alongside normalized levels of harmful homocysteine, which is regulated by the enzyme methionine synthase that methylcobalamin helps activate.
Our findings suggest that methylcobalamin effectively restores nerve myelination in the context of liver disease by addressing underlying biochemical changes. The treatment not only improved myelination but also showed promise in restoring neurobehavioral functions in the rats. This research indicates a potential therapeutic role for vitamin B12 in managing liver-related nerve damage, making it worth further exploration in human studies.
We focused on the hippocampus, an area crucial for memory and learning, where we noted significant reductions in myelin levels and myelin basic protein (MBP) quantities in the affected rats. However, after administering methylcobalamin for a week, we observed a remarkable recovery in the myelination status, alongside normalized levels of harmful homocysteine, which is regulated by the enzyme methionine synthase that methylcobalamin helps activate.
Our findings suggest that methylcobalamin effectively restores nerve myelination in the context of liver disease by addressing underlying biochemical changes. The treatment not only improved myelination but also showed promise in restoring neurobehavioral functions in the rats. This research indicates a potential therapeutic role for vitamin B12 in managing liver-related nerve damage, making it worth further exploration in human studies.
Read More
9
We explored the intriguing question of whether vitamin B12 can provide a protective effect against liver damage caused by acetaminophen, a common painkiller known for its potential hepatotoxicity. In our study, we used male Wister rats and organized them into three groups: one receiving acetaminophen, another treated with vitamin B12, and a control group given distilled water. Each group was administered their respective treatments for a week before we evaluated their liver health.
Our findings indicate that vitamin B12 supplementation significantly improved hepatic health in the rats exposed to acetaminophen. We observed a notable reduction in liver enzyme levels, which is a key marker of liver damage. Additionally, vitamin B12 helped boost antioxidant levels in the body, compensated for a decline in tissue glutathione, and reduced harmful inflammatory markers such as TNF-α and interleukin-6.
Overall, the results of our study suggest that vitamin B12 effectively mitigates acetaminophen-induced liver toxicity by enhancing liver function and reducing inflammation. This insight opens up interesting avenues for considering vitamin B12 as a supportive treatment in managing liver health in cases of acetaminophen exposure.
Our findings indicate that vitamin B12 supplementation significantly improved hepatic health in the rats exposed to acetaminophen. We observed a notable reduction in liver enzyme levels, which is a key marker of liver damage. Additionally, vitamin B12 helped boost antioxidant levels in the body, compensated for a decline in tissue glutathione, and reduced harmful inflammatory markers such as TNF-α and interleukin-6.
Overall, the results of our study suggest that vitamin B12 effectively mitigates acetaminophen-induced liver toxicity by enhancing liver function and reducing inflammation. This insight opens up interesting avenues for considering vitamin B12 as a supportive treatment in managing liver health in cases of acetaminophen exposure.
Read More
Most Useful Reviews
9
Improved blood count
12 people found this helpful
This form of B12 genuinely works, as confirmed by lab results. I struggled with liver disease and pernicious anaemia, leading to severe drops in haemoglobin. After changing to this methylated B12, my haemoglobin levels stabilised and even began to rise. This product, alongside iron supplements, has been crucial in managing my red blood cell count, which has remained above 8.5.
Read More
7.5
Support for cats
2 people found this helpful
I purchased this quality methylcobalamin B12 for my cats with kidney disease to help enhance their energy levels. Each capsule can provide three suitable doses, which is beneficial given that B12 aids in red blood cell production, essential for cats with chronic liver disease. Always consult your vet before administering supplements.
Read More
9
Cleansing diet
This supplement is crucial for diabetics, helping with nerve health and supporting hair growth. It offers wonderful benefits as part of a cleansing diet. It's flavourless and effective for reducing liver disease symptoms, making it suitable across ages. I wholeheartedly recommend it for those needing a radical cleanse.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.7
- All Researches
9
We explored how methylcobalamin, a form of vitamin B12, impacts liver disease, particularly in the context of cholestatic liver failure. The study utilized high-throughput screening to identify methylcobalamin as a specific inhibitor of gasdermin E (GSDME), a protein that plays a key role in pyroptotic cell death—a form of inflammatory cell death contributing to liver damage.
Our findings showed that when tested on mouse models with liver failure due to cholestasis, cisplatin, or concanavalin A, methylcobalamin effectively reduced liver damage. It significantly lowered liver transaminase levels, indicating less liver inflammation and cellular injury, and helped alleviate overall liver cell death.
Furthermore, methylcobalamin worked by preventing the cleavage of GSDME, which is essential for uncontrolled inflammatory cell death. By binding to a specific site on the GSDME protein, it blocked the interactions that trigger this damaging process. Overall, our study highlighted the potential of methylcobalamin as a promising therapeutic option for managing cholestatic liver failure and related conditions.
Our findings showed that when tested on mouse models with liver failure due to cholestasis, cisplatin, or concanavalin A, methylcobalamin effectively reduced liver damage. It significantly lowered liver transaminase levels, indicating less liver inflammation and cellular injury, and helped alleviate overall liver cell death.
Furthermore, methylcobalamin worked by preventing the cleavage of GSDME, which is essential for uncontrolled inflammatory cell death. By binding to a specific site on the GSDME protein, it blocked the interactions that trigger this damaging process. Overall, our study highlighted the potential of methylcobalamin as a promising therapeutic option for managing cholestatic liver failure and related conditions.
Read More
9
Methylcobalamin improves nerve myelination
We delved into the effects of methylcobalamin, a form of vitamin B12, on nerve myelination in rats suffering from moderate hepatic encephalopathy, a condition caused by ammonia toxicity due to liver dysfunction. In our study, we established a model of hepatic encephalopathy by administering thioacetamide to induce liver damage, subsequently leading to changes in nerve myelination in specific brain regions.
We focused on the hippocampus, an area crucial for memory and learning, where we noted significant reductions in myelin levels and myelin basic protein (MBP) quantities in the affected rats. However, after administering methylcobalamin for a week, we observed a remarkable recovery in the myelination status, alongside normalized levels of harmful homocysteine, which is regulated by the enzyme methionine synthase that methylcobalamin helps activate.
Our findings suggest that methylcobalamin effectively restores nerve myelination in the context of liver disease by addressing underlying biochemical changes. The treatment not only improved myelination but also showed promise in restoring neurobehavioral functions in the rats. This research indicates a potential therapeutic role for vitamin B12 in managing liver-related nerve damage, making it worth further exploration in human studies.
We focused on the hippocampus, an area crucial for memory and learning, where we noted significant reductions in myelin levels and myelin basic protein (MBP) quantities in the affected rats. However, after administering methylcobalamin for a week, we observed a remarkable recovery in the myelination status, alongside normalized levels of harmful homocysteine, which is regulated by the enzyme methionine synthase that methylcobalamin helps activate.
Our findings suggest that methylcobalamin effectively restores nerve myelination in the context of liver disease by addressing underlying biochemical changes. The treatment not only improved myelination but also showed promise in restoring neurobehavioral functions in the rats. This research indicates a potential therapeutic role for vitamin B12 in managing liver-related nerve damage, making it worth further exploration in human studies.
Read More
9
We explored the intriguing question of whether vitamin B12 can provide a protective effect against liver damage caused by acetaminophen, a common painkiller known for its potential hepatotoxicity. In our study, we used male Wister rats and organized them into three groups: one receiving acetaminophen, another treated with vitamin B12, and a control group given distilled water. Each group was administered their respective treatments for a week before we evaluated their liver health.
Our findings indicate that vitamin B12 supplementation significantly improved hepatic health in the rats exposed to acetaminophen. We observed a notable reduction in liver enzyme levels, which is a key marker of liver damage. Additionally, vitamin B12 helped boost antioxidant levels in the body, compensated for a decline in tissue glutathione, and reduced harmful inflammatory markers such as TNF-α and interleukin-6.
Overall, the results of our study suggest that vitamin B12 effectively mitigates acetaminophen-induced liver toxicity by enhancing liver function and reducing inflammation. This insight opens up interesting avenues for considering vitamin B12 as a supportive treatment in managing liver health in cases of acetaminophen exposure.
Our findings indicate that vitamin B12 supplementation significantly improved hepatic health in the rats exposed to acetaminophen. We observed a notable reduction in liver enzyme levels, which is a key marker of liver damage. Additionally, vitamin B12 helped boost antioxidant levels in the body, compensated for a decline in tissue glutathione, and reduced harmful inflammatory markers such as TNF-α and interleukin-6.
Overall, the results of our study suggest that vitamin B12 effectively mitigates acetaminophen-induced liver toxicity by enhancing liver function and reducing inflammation. This insight opens up interesting avenues for considering vitamin B12 as a supportive treatment in managing liver health in cases of acetaminophen exposure.
Read More
8
We aimed to understand how vitamin B12 impacts the risk of developing nonalcoholic fatty liver disease (NAFLD). In this study, we used a method called Mendelian randomization, utilizing genetic data as a tool to draw connections between circulating nutrient levels and liver health. By analyzing information from a large group of participants—8434 cases of NAFLD and 770,180 controls—we sought to uncover any potential causal relationships.
Our findings indicated that higher levels of vitamin B12 were associated with a slight increase in the risk of developing NAFLD. Specifically, we observed an odds ratio of 1.08, suggesting that genetic predispositions linked to higher vitamin B12 levels could elevate NAFLD risk. However, it's important to note that this increase may not translate into beneficial effects for liver health as we initially hoped.
Despite thorough sensitivity analyses, the connection we discovered raises questions about the role of vitamin B12 in liver disease, warranting further exploration into its biological mechanisms. The implications of these findings challenge preconceived notions about vitamin B12 and highlight the complexities of nutrient interactions with liver health.
Our findings indicated that higher levels of vitamin B12 were associated with a slight increase in the risk of developing NAFLD. Specifically, we observed an odds ratio of 1.08, suggesting that genetic predispositions linked to higher vitamin B12 levels could elevate NAFLD risk. However, it's important to note that this increase may not translate into beneficial effects for liver health as we initially hoped.
Despite thorough sensitivity analyses, the connection we discovered raises questions about the role of vitamin B12 in liver disease, warranting further exploration into its biological mechanisms. The implications of these findings challenge preconceived notions about vitamin B12 and highlight the complexities of nutrient interactions with liver health.
Read More
We conducted a study to explore the potential benefits of vitamin B12 for liver health in the context of Trypanosoma brucei rhodesiense infection, which causes Human African Trypanosomiasis. Mice were divided into groups, with some receiving vitamin B12 either before or after the infection.
Our findings indicate that vitamin B12 significantly improved the survival rates of infected mice and alleviated liver damage indicators. Specifically, we observed reductions in liver enzymes like alanine aminotransferase and aspartate aminotransferase, which are often elevated in liver disease.
Furthermore, vitamin B12 also lowered levels of total bilirubin and other markers associated with kidney damage. This shows that vitamin B12 not only plays a role in protecting liver functions but also addresses broader health concerns caused by the T.b.r infection.
Overall, our results suggest that vitamin B12 may be a valuable adjunct therapy for managing severe stages of Human African Trypanosomiasis, particularly concerning its protective effects on the liver.
Our findings indicate that vitamin B12 significantly improved the survival rates of infected mice and alleviated liver damage indicators. Specifically, we observed reductions in liver enzymes like alanine aminotransferase and aspartate aminotransferase, which are often elevated in liver disease.
Furthermore, vitamin B12 also lowered levels of total bilirubin and other markers associated with kidney damage. This shows that vitamin B12 not only plays a role in protecting liver functions but also addresses broader health concerns caused by the T.b.r infection.
Overall, our results suggest that vitamin B12 may be a valuable adjunct therapy for managing severe stages of Human African Trypanosomiasis, particularly concerning its protective effects on the liver.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improved blood count
12 people found this helpful
This form of B12 genuinely works, as confirmed by lab results. I struggled with liver disease and pernicious anaemia, leading to severe drops in haemoglobin. After changing to this methylated B12, my haemoglobin levels stabilised and even began to rise. This product, alongside iron supplements, has been crucial in managing my red blood cell count, which has remained above 8.5.
Read More
7.5
Support for cats
2 people found this helpful
I purchased this quality methylcobalamin B12 for my cats with kidney disease to help enhance their energy levels. Each capsule can provide three suitable doses, which is beneficial given that B12 aids in red blood cell production, essential for cats with chronic liver disease. Always consult your vet before administering supplements.
Read More
9
Cleansing diet
This supplement is crucial for diabetics, helping with nerve health and supporting hair growth. It offers wonderful benefits as part of a cleansing diet. It's flavourless and effective for reducing liver disease symptoms, making it suitable across ages. I wholeheartedly recommend it for those needing a radical cleanse.
Read More
7.5
Relieved symptoms
2 people found this helpful
Having tried numerous treatments for Meniere's disease without relief, I found that this fully activated B12 supplement has reduced the fullness in my left ear significantly. I recommend it wholeheartedly to anyone dealing with this condition, especially those with liver disease issues.
Read More
7.5
Lowered liver index
I've purchased this supplement again as it effectively helped with my liver disease. My fatty liver index has decreased significantly since starting the product.
Read More
Frequently Asked Questions
9
Improved blood count
12 people found this helpful
This form of B12 genuinely works, as confirmed by lab results. I struggled with liver disease and pernicious anaemia, leading to severe drops in haemoglobin. After changing to this methylated B12, my haemoglobin levels stabilised and even began to rise. This product, alongside iron supplements, has been crucial in managing my red blood cell count, which has remained above 8.5.
7.5
Lowered liver index
I've purchased this supplement again as it effectively helped with my liver disease. My fatty liver index has decreased significantly since starting the product.
7.5
Relieved symptoms
2 people found this helpful
Having tried numerous treatments for Meniere's disease without relief, I found that this fully activated B12 supplement has reduced the fullness in my left ear significantly. I recommend it wholeheartedly to anyone dealing with this condition, especially those with liver disease issues.
7.5
Support for cats
2 people found this helpful
I purchased this quality methylcobalamin B12 for my cats with kidney disease to help enhance their energy levels. Each capsule can provide three suitable doses, which is beneficial given that B12 aids in red blood cell production, essential for cats with chronic liver disease. Always consult your vet before administering supplements.
9
We explored how methylcobalamin, a form of vitamin B12, impacts liver disease, particularly in the context of cholestatic liver failure. The study utilized high-throughput screening to identify methylcobalamin as a specific inhibitor of gasdermin E (GSDME), a protein that plays a key role in pyroptotic cell death—a form of inflammatory cell death contributing to liver damage.
Our findings showed that when tested on mouse models with liver failure due to cholestasis, cisplatin, or concanavalin A, methylcobalamin effectively reduced liver damage. It significantly lowered liver transaminase levels, indicating less liver inflammation and cellular injury, and helped alleviate overall liver cell death.
Furthermore, methylcobalamin worked by preventing the cleavage of GSDME, which is essential for uncontrolled inflammatory cell death. By binding to a specific site on the GSDME protein, it blocked the interactions that trigger this damaging process. Overall, our study highlighted the potential of methylcobalamin as a promising therapeutic option for managing cholestatic liver failure and related conditions.
Our findings showed that when tested on mouse models with liver failure due to cholestasis, cisplatin, or concanavalin A, methylcobalamin effectively reduced liver damage. It significantly lowered liver transaminase levels, indicating less liver inflammation and cellular injury, and helped alleviate overall liver cell death.
Furthermore, methylcobalamin worked by preventing the cleavage of GSDME, which is essential for uncontrolled inflammatory cell death. By binding to a specific site on the GSDME protein, it blocked the interactions that trigger this damaging process. Overall, our study highlighted the potential of methylcobalamin as a promising therapeutic option for managing cholestatic liver failure and related conditions.
5
We sought to understand how vitamin B12 levels are affected by liver conditions, particularly focusing on non-alcoholic fatty liver disease (NAFLD). In a cross-sectional study involving 1,195 patients, we measured vitamin B12 levels and assessed liver conditions through techniques such as vibration-controlled transient elastography and ultrasonography.
Our findings indicated that vitamin B12 levels were notably lower in patients diagnosed with NAFLD compared to those with other chronic liver diseases. Specifically, the median B12 levels were 289 pg/mL in the NAFLD group versus 313 pg/mL in the others, highlighting a significant difference. We discovered a negative correlation between B12 levels and hepatic steatosis, suggesting that higher fat buildup in the liver corresponds to lower vitamin B12 levels.
Interestingly, we also observed that vitamin B12 levels increased with higher liver stiffness and were particularly significant in patients at the cirrhosis stage. This indicates that while vitamin B12 is reduced with higher steatosis levels, it does not render it ineffective or beneficial as a treatment, since patients with more advanced liver fibrosis generally had higher B12 levels.
Overall, our study enhances the understanding of the relationship between vitamin B12 and liver disease, showing that while there are fluctuations in B12 based on liver condition severity, it does not support the premise of using vitamin B12 as a treatment method for liver diseases.
Our findings indicated that vitamin B12 levels were notably lower in patients diagnosed with NAFLD compared to those with other chronic liver diseases. Specifically, the median B12 levels were 289 pg/mL in the NAFLD group versus 313 pg/mL in the others, highlighting a significant difference. We discovered a negative correlation between B12 levels and hepatic steatosis, suggesting that higher fat buildup in the liver corresponds to lower vitamin B12 levels.
Interestingly, we also observed that vitamin B12 levels increased with higher liver stiffness and were particularly significant in patients at the cirrhosis stage. This indicates that while vitamin B12 is reduced with higher steatosis levels, it does not render it ineffective or beneficial as a treatment, since patients with more advanced liver fibrosis generally had higher B12 levels.
Overall, our study enhances the understanding of the relationship between vitamin B12 and liver disease, showing that while there are fluctuations in B12 based on liver condition severity, it does not support the premise of using vitamin B12 as a treatment method for liver diseases.
8
We aimed to understand how vitamin B12 impacts the risk of developing nonalcoholic fatty liver disease (NAFLD). In this study, we used a method called Mendelian randomization, utilizing genetic data as a tool to draw connections between circulating nutrient levels and liver health. By analyzing information from a large group of participants—8434 cases of NAFLD and 770,180 controls—we sought to uncover any potential causal relationships.
Our findings indicated that higher levels of vitamin B12 were associated with a slight increase in the risk of developing NAFLD. Specifically, we observed an odds ratio of 1.08, suggesting that genetic predispositions linked to higher vitamin B12 levels could elevate NAFLD risk. However, it's important to note that this increase may not translate into beneficial effects for liver health as we initially hoped.
Despite thorough sensitivity analyses, the connection we discovered raises questions about the role of vitamin B12 in liver disease, warranting further exploration into its biological mechanisms. The implications of these findings challenge preconceived notions about vitamin B12 and highlight the complexities of nutrient interactions with liver health.
Our findings indicated that higher levels of vitamin B12 were associated with a slight increase in the risk of developing NAFLD. Specifically, we observed an odds ratio of 1.08, suggesting that genetic predispositions linked to higher vitamin B12 levels could elevate NAFLD risk. However, it's important to note that this increase may not translate into beneficial effects for liver health as we initially hoped.
Despite thorough sensitivity analyses, the connection we discovered raises questions about the role of vitamin B12 in liver disease, warranting further exploration into its biological mechanisms. The implications of these findings challenge preconceived notions about vitamin B12 and highlight the complexities of nutrient interactions with liver health.
References
- Xu W, Wang Y, Cui S, Zheng Q, Lin Y, et al. Methylcobalamin protects against liver failure via engaging gasdermin E. Nat Commun. 2025;16:1233. doi:10.1038/s41467-024-54826-6
- Abu-Zahab ZA, Qureshi H, Adham GM, Elzefzafy WM, Zalam SS, et al. Frequency of comorbid diseases with high serum Vitamin B12 levels in patients attending King Salman Medical City (KSAMC), at Madinah. Int J Health Sci (Qassim). 2025;19:15.
- Espina S, Casas-Deza D, Bernal-Monterde V, Royo-Esteban A, García-Sobreviela MP, et al. Unraveling the Association of Liver Steatosis and Fibrosis with Vitamin B12: A Cross-Sectional Study. Metabolites. 2024;14. doi:10.3390/metabo14110618
- Roy A, Trigun SK. The restoration of hippocampal nerve de-myelination by methylcobalamin relates with the enzymatic regulation of homocysteine level in a rat model of moderate grade hepatic encephalopathy. J Biochem Mol Toxicol. 2024;38:e23695. doi:10.1002/jbt.23695
- Pai SL, Torp KD, Insignares VC, DeMaria S, Giordano CR, et al. Use of hydroxocobalamin to treat intraoperative vasoplegic syndrome refractory to vasopressors and methylene blue during liver transplantation. Clin Transplant. 2024;38:e15271. doi:10.1111/ctr.15271
- Liu K, Chen Y, Chen J, Chen W, Sun X, et al. Genetically determined circulating micronutrients and the risk of nonalcoholic fatty liver disease. Sci Rep. 2024;14:1105. doi:10.1038/s41598-024-51609-3
- Boachie J, Zammit V, Saravanan P, Adaikalakoteswari A. Metformin Inefficiency to Lower Lipids in Vitamin B12 Deficient HepG2 Cells Is Alleviated via Adiponectin-AMPK Axis. Nutrients. 2023;15. doi:10.3390/nu15245046
- Oula JO, Mose JM, Waiganjo NN, Chepukosi KW, Mitalo NS, et al. Vitamin B12 blocked Trypanosoma brucei rhodesiense-driven disruption of the blood brain barrier, and normalized nitric oxide and malondialdehyde levels in a mouse model. Parasitol Int. 2023;96:102775. doi:10.1016/j.parint.2023.102775
- Ujianti I, Sianipar IR, Prijanti AR, Hasan I, Arozal W, et al. Effect of Roselle Flower Extract ( Linn.) on Reducing Steatosis and Steatohepatitis in Vitamin B12 Deficiency Rat Model. Medicina (Kaunas). 2023;59. doi:10.3390/medicina59061044
- Ahmed Mohammed R, Fadheel QJ. Hepatoprotective Effect of Vitamin B12 in Acetaminophen Induce Hepatotoxicity in Male Rats. Arch Razi Inst. 2023;78:419. doi:10.22092/ARI.2022.359353.2408
